| 1638 | | 29 Mar:
Swedish colonists establish a settlement near present day Wilmington, Delaware, naming it Nya Sverige, New Sweden.F&P DEGov |
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| 1681 | | 4 Mar:
William Penn receives a charter for "New Wales", which became "Sylvania" and finally Pennsylvania.XPH HSP |
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| 1683 | |
| 1733 | | 17 May:
Britain passes the Molasses Act putting high tariffs on rum and molasses imported to the Colonies from anyplace other than Britain and its possessions.GoogleBooks JotAR |
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| 1752 | | 14 Sep:
The British Empire adopts the Gregorian calendar.CSL CalWiz |
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| 1753 | | 11 Feb:
The first patients are admitted to the first hospital in America, Pennsylvania Hospital, founded by Dr. Thomas Bond and Benjamin Franklin in 1751.PennMed UMW |
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| 1754 | |
| 1758 | | 25 Nov:
Fort Duquesne is captured from the French, which will later become Pittsburgh, Pennsylvania.F&IWS |
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| 1765 | | 22 Mar:
The Stamp Act is passed by the British Parliament - a tax imposed on American colonists on any printed paper.GLIoAH Avalon |
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| | 1 Nov:
The Stamp Act goes into effect - a tax on the Colonies to fund the British Military in America.CC SAH |
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| 1774 | |
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| 1775 | | 19 Apr:
The first battles of the American Revolution. British troops fight American Minutemen at Lexington, killing eight. The British then move to Concord where they again engage the colonials. By the end of the battle, 93 colonists are dead. The British, having lost 273, retreat to Boston.LoC NPS |
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| 1776 | | 9 Jan:
Thomas Paine publishes Common Sense.CC BookRags |
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| | 4 Jul:
The United States is founded when the Second Continental Congress declares its independence from Great Britain.USHistory USNA |
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| 1783 | |
| 1787 | |
Pennsylvania