| 1796 | |
| 1797 | | 2 May:
Lorenzo Carter becomes the first permanent settler of Cleveland.CH TCD |
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| 1803 | |
| 1813 | | 10 Sep:
The U. S. Fleet defeats the British Royal Navy in the Battle of Lake Erie.OHC NPS |
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| 1816 | |
The previous year, Mt. Tambora erupted producing so much ash and gas the sunlight was blocked from warming the earth causing the "Year Without Summer".USGS |
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| 1852 | | 20 Mar:
Harriet Beecher Stowe's Uncle Tom's Cabin is published.NCC SIMag |
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| 1853 | | 1 Apr:
The first professional U. S. fire department is established in Cincinnati, Ohio.CFD CO.gov |
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| 1876 | | 2 Feb:
The National League of Professional Baseball Clubs, which comes to be more commonly known as the National League is formed.Reds SABR |
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| 1880 | | 2 Nov:
James Abram Garfield is elected the 20th president of the United States of America. Garfield is wounded by an assassin's bullet on 3 Jul 1881 and dies on 19 Sep 1881.USEA USHouse |
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| 1886 | |
| 1892 | | 27 Sep:
Book matches receive a patent.PSU Hagley |
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| 1908 | | 6 Oct:
Henry S. Winzeler founds the Ohio Art Company, makers of the Etch-A-Sketch.GoogleNews |
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| 1911 | | 17 Feb:
The first electric "self-starter" is installed in a Cadillac.Hemmings EC |
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| 1913 | | 31 Oct:
The first transcontinental highway, the Lincoln Highway, is dedicated.DOT ILH |
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| 1914 | |
| | 1 Sep:
Martha, the last passenger pigeon, dies at the Cincinnati Zoological Garden.SI Audubon |
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| 1915 | | 17 Aug:
Charles F. Kettering, co-founder of DELCO in Dayton, Ohio, is issued a patent for his "engine-starting device".OAC AN |
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| 1918 | | 21 Feb:
The last known Carolina Parakeet dies in captivity at the Cincinnati Zoo.Audubon USC |
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| 1920 | | 20 Aug:
Seven men, including legendary all-around athlete and football star Jim Thorpe, meet to organize a professional football league in Canton, Ohio.OHC DT |
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| | 2 Nov:
Warren Gamaliel Harding is elected the 29th president of the United States of America. He dies of a heart attack in San Francisco on 2 August 1923. USEA LoC |
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| 1922 | |
| 1930 | | 21 Apr:
320 inmates die in a fire at the Ohio State Penitentiary in Columbus, many burning to death when their cell doors are not unlocked.OHC QRFS |
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| 1935 | | 24 May:
Major League Baseball plays its first night game.SABR NBHoF |
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| 1947 | | 11 May:
The B.F. Goodrich Co. announces the development of the tubeless tire.History.com DA |
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| 1950 | | 24 Sep:
Black Sunday occurs when smoke from forest fires in western Canada makes its way east, darkening the skies in the eastern United States and Canada and as far away as western Europe.BLM WR |
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| |
| 1956 | | 22 Dec:
A gorilla named Colo is born at the Columbus Zoo in Ohio - the first gorilla in the world born in captivity.CZ OHC |
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| 1969 | | 22 Jun:
The Cuyahoga River catches fire because of its polluted waters.W I R E D OHC |
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| 1970 | | 4 May:
Members of the Ohio National Guard fire into a crowd of Kent State University demonstrators, killing four and wounding nine.KSU ABJ |
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| 1978 | |
| 1986 | |
| 2003 | |