William Appleton was born about 1510 in London, co. Middlesex, England. He died on 24 Aug 1538. He signed a will on 20 Sep 1538. His estate was probated on 2 May 1539. He was married to Rose Sexton about 1530.

Rose Sexton. Children were:

i. Frances Appleton died before 20 Jul 1571.
ii. Thomas Appleton Esq..