Ephraim Kempton was baptized on 26 Oct 1591 in Berwick-Upon-Tweed, co. Northumberland, England. He was educated at Merchant Taylors' School from 1630 to 1635 in London, co. Middlesex, England. He died before 5 May 1645 in Scituate, Plymouth Co., Massachusetts. The inventory of his estate was taken on 5 May 1645. He was married to Elizabeth Wilson on 12 Apr 1617 in Holy Trinity The Less, London, co. Middlesex, England.

Elizabeth Wilson was born between 1590 and 1599. She died between 1620 and 1640. Children were:

i. John Kempton was baptized on 22 Nov 1618 in Holy Trinity The Less, London, co. Middlesex, England. He was educated at Merchant Taylors' School from 1630 to 1634 in London, co. Middlesex, England.
ii. Ephraim Kempton.